6-Methyl-2-(4-Methylphenyl)Imidazol[1,2-A]-Pyridine-3-
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester
CAS: 258273-50-6
Molecular Formula: C18H18N2O2
6-Methyl-2-(4-Methylphenyl)Imidazol[1,2-A]-Pyridine-3- - Names and Identifiers
6-Methyl-2-(4-Methylphenyl)Imidazol[1,2-A]-Pyridine-3- - Physico-chemical Properties
| Molecular Formula | C18H18N2O2 |
| Molar Mass | 294.35 |
| Density | 1.16±0.1 g/cm3(Predicted) |
| pKa | 6.48±0.50(Predicted) |
| Storage Condition | 2-8°C |
| Refractive Index | 1.599 |
6-Methyl-2-(4-Methylphenyl)Imidazol[1,2-A]-Pyridine-3- - Introduction
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester is an organic compound with the chemical formula C17H16N2O2.
Nature:
1. Appearance: A white or light yellow crystalline solid.
2. Melting Point: about 82-83 ℃.
3. Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and Ether solvents.
Use:
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester is commonly used as an intermediate in organic synthesis. It can be used to synthesize a variety of biologically active compounds, including drugs, pesticides and dyes.
Method:
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester can be synthesized by the following steps:
1.4-methyl benzaldehyde and ethyl acetate are reacted to obtain the corresponding 4-Methyl phenyl ethyl acetate.
2. Reaction of ethyl 4-methylphenylacetate with formaldehyde and naphthylimidazole in the presence of a catalyst gives 6-methyl -2-(4-methylphenyl) imidazole [1,2-a] pyridin-3-ol.
3. Finally, 6-methyl-2-(4-methylphenyl) imidazole [1,2-a] pyridin-3-ol was reacted with formic acid to give 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester.
Safety Information:
The toxicity and danger of 6-methyl-2-( 4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester has not been clearly reported or evaluated. But in general, when handling organic compounds, pay attention to personal protection and avoid direct contact with skin and eyes. During use, the laboratory's safe operation procedures should be followed and good ventilation should be carried out.
Nature:
1. Appearance: A white or light yellow crystalline solid.
2. Melting Point: about 82-83 ℃.
3. Solubility: Soluble in organic solvents such as ethanol, dimethylformamide and Ether solvents.
Use:
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester is commonly used as an intermediate in organic synthesis. It can be used to synthesize a variety of biologically active compounds, including drugs, pesticides and dyes.
Method:
6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester can be synthesized by the following steps:
1.4-methyl benzaldehyde and ethyl acetate are reacted to obtain the corresponding 4-Methyl phenyl ethyl acetate.
2. Reaction of ethyl 4-methylphenylacetate with formaldehyde and naphthylimidazole in the presence of a catalyst gives 6-methyl -2-(4-methylphenyl) imidazole [1,2-a] pyridin-3-ol.
3. Finally, 6-methyl-2-(4-methylphenyl) imidazole [1,2-a] pyridin-3-ol was reacted with formic acid to give 6-methyl-2-(4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester.
Safety Information:
The toxicity and danger of 6-methyl-2-( 4-methylphenyl)imidazo[1,2-a]-pyridine-3-acetate,methyl ester has not been clearly reported or evaluated. But in general, when handling organic compounds, pay attention to personal protection and avoid direct contact with skin and eyes. During use, the laboratory's safe operation procedures should be followed and good ventilation should be carried out.
Last Update：2024-04-09 21:00:56
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